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"Storage Conditions (Product)", "Value": "Special Stains Van Gieson CS should be stored at 15-30°C.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Intended Use", "Value": "Special Stains Van Gieson CS used in conjunction with Elastic Stain Core Kit is intended for laboratory use in staining non-target tissue components and providing contrast with target stains in sections of formalin-fixed, paraffin-embedded (FFPE) tissue stained on a BenchMark Special Stains instrument. 
This reagent is intended as a counterstain in special stains applications. 

This product is intended for in vitro diagnostic (IVD) use.
 ", "Language": "en", "Country": "XG", "Code": "Intended Use" }, { "Name": "Background Information", "Value": "The counterstain (CS), Special Stains Van Gieson CS, used in conjunction with the Elastic Stain Core Kit is a modification of the Verhoeff’s Van Gieson method that demonstrates elastic fibers within tissues.In 1908 F.H. Verhoeff developed a histochemical stain that could differentiate elastic fibers from collagen and other connective tissue when used in conjunction with Van Gieson’s stain.2 Vascular diseases, both genetic and acquired, are associated with elastic fiber defects that alter arterial function.3 In these diseases, elastic fibers are degraded or dysfunctional, which can be caused by biochemical modifications, disorganization, or fragmentation.3

The elastic staining pattern within blood vessels is used to aid pathologist in the diagnosis of vascular disease.

1. Piccinin M, Schwartz J. Histology, Verhoeff Stain. In Treasure Island, FL: StatPearls; 2020.
2. Kazlouskaya V, Malhotra S, Lambe J, Idriss MH, Elston D, Andres C. The utility of elastic Verhoeff-Van Gieson staining in dermatopathology. J Cutan Pathol. 2013;40(2):211-225.
3. Cocciolone AJ, Hawes JZ, Staiculescu MC, Johnson EO, Murshed M, Wagenseil JE. Elastin, arterial mechanics, and cardiovascular disease. Am J Physiol Heart Circ Physiol. 2018;315(2):H189-H205", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "Verhoeff’s Van Gieson method is a regressive stain. Dye binding occurs mainly via Van der Waals forces and hydrogen bonds. Verhoeff’s elastic stain binds to elastic fibers with higher affinity than compared to other cell structures. The Ferric Chloride Oxidizer oxidizes the Hematoxylin to hematein. Hematein is a compound that has high affinity for iron together with the second mordant, Lugol’s Iodine, to form an iron hematein complex and chelates with the elastic fibers in the tissue. The Differentiator uses lower strength of ferric chloride. This step is used to differentiate the target stain from non-specific binding. The rinsing of the Differentiator removes the loosely bound stain from cell structures other than elastic fibers.

The Special Stains Van Gieson CS stains red blood cells and muscle yellow and collagen pink to provide contrast with the dark purple to black elastic fibers.

This kit is optimized for use on BenchMark Special Stains instruments. The reagents are applied to tissue on microscope slides and mixed over the entire specimen.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Content", "Value": "The reagent vial is supplied in barcode labeled carriers to insert into the reagent tray of the instrument. Each kit contains sufficient reagent for 50 tests.

One 27 mL vial of Special Stains Van Gieson CS contains 0.6% picric acid and 0.02% acid fuchsin.
One vial insert with sipping straw.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Product Purpose", "Value": "Special Stains Van Gieson CS used in conjunction with Elastic Stain Core Kit is intended for laboratory use in staining non-target tissue components and providing contrast with target stains in sections of formalin-fixed, paraffin-embedded (FFPE) tissue stained on a BenchMark Special Stains instrument. 
This reagent is intended as a counterstain in special stains applications. 

This product is intended for in vitro diagnostic (IVD) use.
 ", "Language": "en", "Country": "XG", "Code": "Product Purpose" } ] } } ] }

Special Stains Van Gieson CS

IVD For in vitro diagnostic use.
Special Stains Van Gieson CS

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