IVD
For in vitro diagnostic use.
CONFIRM™ anti-c-KIT (9.7) Primary Antibody
This antibody is intended for in vitro diagnostic (IVD) use.Ventana Medical Systems' (Ventana) CONFIRM anti-c-KIT (9.7) Primary Antibody is a rabbit monoclonal antibody (IgG) directed against the C terminal (intracellular) domain of c- KIT protein and recognizes both wild type and mutant forms of the c-KIT protein. This antibody is intended for laboratory use, via light microscopy, for the qualitative detection of c-KIT protein in formalin-fixed, paraffin-embedded tissue on a Ventana automated slide stainer. CONFIRM anti-c-KIT (9.7) specifically binds to antigen located in the cell membrane and cytoplasmic regions of normal mast cells, interstitial cells of Cajal (ICC), and gastrointestinal stromal tumors (GISTs).This antibody does not cross react with PDGFR alpha, c-FMS or Flt-3. The presence of c-KIT protein in GISTs is helpful diagnostically in the identification of GISTs and their separation from other stromal lesions.1 The clinical interpretation of any staining, or the absence of staining, must be complemented by morphological studies and evaluation of proper controls. Evaluation must be made by a qualified pathologist within the context of the patient’s clinical history and other diagnostic tests. Prescription only. 1. Sarlomo-Rikala M, Kovatich H, Barusevicius A, Miettinen M. CD117: A sensitive marker for gastrointestinal stromal tumors that is more specific than CD34. Mod Pathol (1998) 11: 728-734.