Raw material for use in laboratory developed tests (LDTs)/ Analyte Specific Reagent*
Figure 1. Two of the early HPV genes encode for the oncoproteins E6 and E7. mRNA transcription in cells indicates active viral processes. Overexpression of E6 and E7 mRNA precedes transformation of cells. In persistent high risk HPV infections, E6 and E7 oncoproteins disrupt the p53 and retinoblastoma protein (pRb) cell cycle control mechanisms respectively.
* Analytical and performance characteristics are not established.