For years, molecular testing laboratories have trusted the MagNA Pure family to dramatically reduce handling errors with reliable and simplified sample preparation. Building on this legacy, the MagNA Pure 24 System is a fully-automated clinical nucleic acid extraction system that brings you walkaway automation, designed to minimize user intervention and extraction-to-extraction variability.
The universal MagNA Pure 24 Total Nucleic Acid Kit eliminates unnecessary complexity, enabling efficient extraction of nucleic acid from 10 prevalidated human sample types with one universal reagent kit. Reuse reagent cassettes for later use by sealing them and let the system identify and track reagent usage with on-board barcode scanning.
The MagNA Pure 24 System gives you the flexibility to extract up to 10 different human sample types with a single universal reagent kit. Rely on this simplified reagent concept and choose one of the pre-optimized and pre-programmed protocols to extract from mixed batch sample types and primary tubes within one protocol.
The MagNA Pure 24 System isn’t just automated. It offers true walkaway operation with easy barcoded surveillance and minimal user interaction, so you can reduce human error and save valuable time.
Confidence in your eluate is everything when it comes to molecular testing. The MagNA Pure 24 System is an IVD/CE-IVD instrument and comes with surveillance features to ensure the highest quality of eluate while reducing human error.
IVD
MagNA Pure 24 System technical video
Access package inserts through your country’s Roche Diagnostics website.
The MagNA Pure 24 System protocols are available for download from the table below (note: not available for download in the US).
The following protocols have been updated:
In order to be able to access the new protocols listed above, the sequence of setting is as follows:
Step 1: select reagent cassette of "Total NA Isolation Kit 1.1"
Step 2: select sample type
Step 3: select sample volume
Step 4: select protocol
| Target | Protocol name | Input sample type and sample volumes | Elution volume | Run time♰ (h:mm) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Whole blood | Plasma | Serum | Nasal swabs* | BAL** |
Urine | Stool | Cultured cells | Fresh-frozen tissue | FFPET*** | ||||
| Baterial, fungal and viral NA |
Pathogen 200
Protocol optimized for speed |
200 μL | 50 or 100 μL | 1:22 | |||||||||
|
Fast Pathogen 200
8 sample protocol optimized for speed, yield and purity |
0:35 | ||||||||||||
|
Pathogen 1000
Protocol optimized for yield and purity |
500 or 1000 μl | 1:40 | |||||||||||
|
External Lysis Pathogen 200
External Lysis Pathogen 500 Protocols optimized with external lysis buffer |
450 μl lysate from 200 μl sample 1450 μl lysate from 500 μl sample |
1:30 | |||||||||||
| 1:40 | |||||||||||||
| Genomic DNA |
hgDNA 200
Protocol optimized for human genomic NA |
200 μl (≤ 2x106 cells) | Up to 5x105 | Up to 5 mg | 1:15 | ||||||||
|
Fast hgDNA 200
8 sample protocol optimized for speed |
0:25 | ||||||||||||
|
hgDNA ds 200
Protocol optimized for NGS |
1:15 | ||||||||||||
|
hgDNA 1000
Protocol optimized for yield and purity |
500 μl (≤ 5x106 cells) 1000 μl (≤ 1x107 cells) |
100 or 200 μl | 2:25 | ||||||||||
| Up to 1x106 | |||||||||||||
|
DNA FFPET 1000
Deparaffinization and lysis on board |
Up to 6 x 5 μm sections (up to 6 mm3) | 50 or 100 μl | 5:30 | ||||||||||
| Cell-free NA |
cfNA ss 2000
cfNA ss 4000 Protocol optimized for single-stranded DNA |
2000 μL | 50 or 100 μL | 2:05 | |||||||||
| 4000 μL | 3:00 | ||||||||||||
|
cfNA ds 2000
cfNA ds 4000 Protocol optimized for double-stranded DNA |
2000 μL | 100, 150 or 200 μL | 2:30 | ||||||||||
| 4000 μL | 3:30 | ||||||||||||
|
cfNA ds 4000 hp
Protocol optimized for double-stranded DNA and NGS |
4000 μL | 60 or 150 μL | 4:40 | ||||||||||
| Post elution | Sample Transfer to the processing cartridge | 200 μL 500 μL 1000 μL |
0.08 | ||||||||||
| PCR Setup for 2-25 μL per eluate for PCR Sstup in Frame-Strip with flat caps-Low Profile or LightCycler® 8-tube strips | 0.05 | ||||||||||||
| Archiving for 2-25 μL per eluate for PCR Sstup in FrameStrip low Profile strips or LightCycler® 8-tube strips | 0.05 | ||||||||||||
