SOX-10 (SP267) Rabbit Monoclonal Primary Antibody is intended for laboratory use in the detection of the SOX-10 protein in formalin-fixed, paraffin-embedded tissue stained on BenchMark immunohistochemical (IHC/ISH) automated slide stainers. SOX-10 is a nuclear transcription factory that participates in neural crest development and in the specification and differentiation of cells of melanocytic lineage.1
CONFIRM anti-MART-1/melan A (A103) Mouse Monoclonal Primary Antibody
CONFIRM anti-MART-1/melan A (A103) Mouse Monoclonal Primary Antibody is a mouse monoclonal antibody (IgG1) directed against melan A. Positive staining may aid in the classification of melanoma.2,3
Kelsch RN. Sorting out SOX10 functions in neural crest development. BioEssays. 2006; 28:788
Chen YT, Stockert E, Jungbluth A, Tsang S, Coplan KA, Scanlan MJ, Old LJ. Serological analysis of Melan-A (MART-1), a melanocyte-specific protein homogeneously expressed in human melanomas. Proc Natl Acad Sci U S A 1996 Jun 11;93(12):5915-9.
Jager e, Ringhoffer M, Karbach J, Arand M, Oesch F, Knuth A. Inverse relationship of melanocyte differentiation antigen expression in melanoma tissues and CD8+ cytotoxic T-cell responses: evidence for immunoselection of antigen-loss variants in vivo. Int J Cancer. 1996 May 16;66(4):470-6.
Comprehensive melanoma panel
Melanoma accounts for only 1% of all skin cancer cases, but causes the most skin cancer deaths.
Additional derm-related markers to meet a broad range of diagnostic needs including:
Squamous cell vs. basal cell carcinomas
Fully automated, direct immunofluorescence staining
Greater context for diagnosis with brown and red chromogens
Simpler, faster interpretation
Compatible with any species combination of mouse and rabbit primary antibodies (mouse-mouse, rabbit-rabbit, rabbit-mouse)
Sensitive and specific detection in red or brown chromogens
ultraView Universal Alkaline Phosphatase Red Detection Kit and ultra View Universal DAB Detection Kit ultraView detection systems are leading-edge multimer-technology based kits suitable for use with both mouse and rabbit primary antibodies. ultraView chemistry provides crisp morphology, enabling the sensitive and specific visualisation of the targeted antigen. The kits are biotin-free, thus eliminating non-specific staining caused by endogenous biotin.
OptiView DAB IHC Detection Chemistry By increasing the numbers of HRP enzymes at each primary antibody site, OptiView DAB IHC detection provides unparalleled signal intensity, empowering you to achieve the level of intensity you desire, even for low-expressing antigens. Our synthetic, non-endogenous hapten system virtually eliminates background even as signal intensity increases.
IHC and ISH reagents and ancillaries
To view associated reagents, ancillaries and bulks, please visit the Roche Tissue Diagnostics reagent catalog.