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{
"Name": "Background Information",
"Value": "T-cells are white blood cells that recognize foreign antigens, stimulate B-cell differentiation, and elicit immune-mediated cell death.1,2 As T-cells mature, they express and retract various surface markers such as cluster of differentiation (CD) molecules, allowing an immunophenotypic method to identify lymphocytes based on the markers they express.1,2 T-cell leukemias and lymphomas are heterogeneous lymphoproliferative disorders, resulting from the clonal expansion of a T-cell that originates from either the bone marrow or a secondary lymphoid structure, respectively.1,2
CD8 is a 68 kDa heterodimeric, transmembrane glycoprotein expressed by cytotoxic T- cells and at low levels in NK-cells and a subpopulation of bone marrow cells.2-4 CD8 acts as a co-receptor for the T-cell receptor and interacts directly with major histocompatibility complex class I molecules on antigen-presenting cells, which stimulate T-cell activation.2,4 CD8 is absent on immature T-cells and expressed in later stages of T-cell development as the cell matures into a cytotoxic T-cell.1,5 CD8 is generally expressed in neoplasms derived from cytotoxic T-cells and is generally absent in lymphomas derived from helper T-cells.2-5 Some T-cell lymphomas, such as anaplastic large cell lymphoma, mycosis fungoides,andperipheral T-cell lymphoma may aberrantly express CD8.2,3,5
The detection of CD8 by immunohistochemistry (IHC) with the anti-CD8 (SP239) Rabbit Monoclonal Primary Antibody (anti-CD8 (SP239) antibody) maybe used to aid in the identification of a subset of normal T-cells and sub-classification of T-cell lymphoma.
1. Rich R, Fleisher T, Shearer W, Frew A, Weyand C. Clinical Immunology Principles and Practice, 5th edition. Vol 5. Amsterdam, Netherlands: Elsevier; 2018.
2. Dabbs DJ. Diagnostic Immunohistochemistry Theranostic and Genomic Applications, 5th edition. Vol 5. Amsterdam, Netherlands: Elsevier; 2019.
3. Higgins RA, Blankenship JE, Kinney MC. Application of immunohistochemistry in the diagnosis of non-Hodgkin and Hodgkin lymphoma. Arch Pathol Lab Med. 2008;132(3):441-461.
4. Naeim F. Principles of Immunophenotyping. In: Naeim F, Rao PN, Grody WW, eds. Hematopathology: Morphology, Immunophenotype, Cytogenetics, and Molecular Approaches. Cambridge, MA: Academic Press; 2009.
5. Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edition. Vol 4. Lyon, France: International Agency for Research on Cancer; 2008.",
"Language": "en",
"Country": "XG",
"Code": "Background Information"
},
{
"Name": "Principle",
"Value": "Anti-CD8 (SP239) antibody binds to the CD8 glycoproteinin formalin-fixed, paraffin- embedded (FFPE) tissue sections. This antibody can be visualized using OptiView DAB IHC Detection Kit (Cat. No. 760-700 / 06396500001) or ultraView Universal DAB Detection Kit (Cat. No. 760-500 / 05269806001). Refer to the respective method sheet for further information.",
"Language": "en",
"Country": "XG",
"Code": "Principle"
},
{
"Name": "Content",
"Value": "Anti-CD8 (SP239) antibody contains sufficient reagent for 50 tests.
One 5 mL dispenser of anti -CD8 (SP239) antibody contains approximately 51.0μg of a rabbit monoclonal antibody.
The antibody is diluted in a phosphate buffer containing carrier protein and 0.10% ProClin 300, a preservative.
Specific antibody concentration is approximately 10.2 μg/mL. There is no known non-specific antibody reactivity observed in this product.
Anti-CD8 (SP239) antibody is a recombinantrabbit monoclonal antibody produced as purified cell culture supernatant.",
"Language": "en",
"Country": "XG",
"Code": "Content"
},
{
"Name": "Product Purpose",
"Value": "Le anti-CD8 (SP239) Rabbit Monoclonal Primary Antibody est destiné à être utilisé en laboratoire pour la détection immunohistochimique qualitative par microscopie optique de CD8 dans des coupes de tissus fixés au formol et inclus en paraffine colorées sur un appareil BenchMark IHC/ISH.
Ce produit doit être interprété par un anatomopathologiste qualifié, en complément d’examens histologiques, d’informations cliniques pertinentes et de contrôles adaptés.
Cet anticorps est conçu pour une utilisation en diagnostic in vitro (IVD).",
"Language": "fr",
"Country": "XG",
"Code": "Product Purpose"
}
]
}
}
]
}
