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Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Intended Use", "Value": "Le CONFIRM anti-bcl-2 (124) Mouse Monoclonal Primary Antibody est destiné à être utilisé en laboratoire pour la détection immunohistochimique qualitative par microscopie optique de la protéine bcl-2 (B-cell lymphoma 2) dans des coupes de tissus fixés au formol et inclus en paraffine (FFPE) colorées sur un appareil BenchMark IHC/ISH.

Ce produit doit être interprété par un anatomopathologiste qualifié, en complément d’examens histologiques, d’informations cliniques pertinentes et de contrôles adaptés.

Cet anticorps est conçu pour une utilisation en diagnostic in vitro (IVD).", "Language": "fr", "Country": "XG", "Code": "Intended Use" }, { "Name": "Content", "Value": "CONFIRM anti-bcl-2 (124) antibody contains sufficient reagent for 50 tests.

One 5 mL dispenser of CONFIRM anti-bcl-2 (124) antibody contains approximately 85 μg of a mouse monoclonal antibody.

The antibody is diluted in 0.05 M Tris-HCI with approximately 1% carrier protein, and 0.10% ProClin 300, a preservative.

Specific antibody concentration is approximately 17 μg/mL. There is no known non-specific antibody reactivity observed in this product.

CONFIRM anti-bcl-2 (124) antibody is a recombinant mouse monoclonal antibody produced as purified cell culture supernatant.

Refer to the appropriate VENTANA detection kit method sheet for detailed descriptions of: Principle of the Procedure, Material and Methods, Specimen Collection and Preparation for Analysis, Quality Control Procedures, Troubleshooting, Interpretation of Results, and General Limitations.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Background Information", "Value": "CONFIRM anti-bcl-2 (124) Mouse Monoclonal Primary Antibody (CONFIRM anti-bcl-2 (124) antibody) is directed against human bcl-2 protein. The bcl-2 oncoprotein plays a central role in apoptosis, serving as an inhibitor of the apoptotic process, and it has given name to a family of proteins engaged in the promotion/inhibition of apoptosis.¹ The expression of bcl-2 proved to block programmed cell death rather than promote proliferation. Bcl-2 is normally expressed in T cells, pre-B cells, resting B cells including normal mantle zone lymphocytes, and certain types of proliferating B cells.^2,3 However, bcl-2 is down-regulated in normal germinal center B cells.^2,3 Among neoplastic tissues, high bcl-2 levels are detected in most human small mature B-cell lymphomas (e.g., chronic lymphocytic leukemia/small lymphocytic lymphoma, follicular lymphoma, mantle cell lymphoma and marginal zone lymphoma), whereas it is expressed to varying degrees in diffuse large B-cell lymphoma, Hodgkin lymphoma and T-cell lymphoma.^2,4 Burkitt’s lymphoma is typically bcl-2-negative, although weak expression is observed in some cases.^2,4,5 Furthermore, bcl-2 expression is also detected in many non-hematopoietic malignancies, including non-small cell lung cancer, breast cancer, colon cancer, and melanoma.⁶ The mechanisms underlying bcl-2 overexpression vary widely in these neoplasms, and include chromosomal translocation, gene amplification, and microRNA dysregulation.⁶

Bcl-2 overexpression is a hallmark of follicular lymphoma; the vast majority of follicular lymphoma have the characteristic t(14;18) chromosomal translocation that puts the bcl-2 gene under the control of the IgH promoter, leading to its overexpression.^7,8 Thus, the detection of bcl-2 by immunohistochemistry (IHC) with CONFIRM anti-bcl-2 (124) antibody may be used as an aid in the identification of follicular lymphoma.

Per the 2016 revised WHO classification of lymphoid neoplasms, once the diagnosis of diffuse large B-cell lymphoma (DLBCL) is established, further characterization is required.⁹ DLBCL can be characterized by cell of origin, molecular features, and genetic or mutational landscape.¹⁰ Bcl-2 IHC is often performed in this context. Thus, the detection of bcl-2 by IHC with CONFIRM anti-bcl-2 (124) antibody may be used as an aid in the characterization of DLBCL.

Bcl-2 expression is downregulated in normal germinal center B-cells in reactive tissues, whereas it is overexpressed in the neoplastic follicles of follicular lymphoma.⁷ Thus, the detection of bcl-2 by IHC with CONFIRM anti-bcl-2 (124) antibody may be used as an aid in the differentiation of follicular lymphoma from benign reactive follicles.

The staining pattern for this antibody is cytoplasmic. It may be used as part of a panel of IHC studies.

1. Chao DT, Korsmeyer SJ. BCL-2 family: regulators of cell death. Annu Rev Immunol. 1998;16:395-419.
2. Higgins RA, Blankenship JE, Kinney MC. Application of Immunohistochemistry in the Diagnosis of Non-Hodgkin and Hodgkin Lymphoma. Arch Pathol Lab Med. 2008;132(3):441-461.
3. Hsi ED, Yegappan S. Lymphoma Immunophenotyping: A New Era in Paraffin-Section Immunohistochemistry. Adv Anat Pathol. 2001;8(4):218-239.
4. Klanova M, Klener P. Bcl-2 Proteins in Pathogenesis and Therapy of B-Cell Non-Hodgkin Lymphomas. Cancers (Basel). 2020;12(4).
5. Masque-Soler N, Szczepanowski M, Kohler CW, et al. Clinical and Pathological Features of Burkitt Lymphoma Showing Expression of Bcl2--an Analysis Including Gene Expression in Formalin-Fixed Paraffin-Embedded Tissue. Br J Haematol. 2015;171(4):501-508.
6. Correia C, Lee SH, Meng XW, et al. Emerging Understanding of Bcl-2 Biology: Implications for Neoplastic Progression and Treatment. Biochim Biophys Acta. 2015;1853(7):1658-1671.
7. Dabbs DJ. Diagnostic Immunohistochemistry: Theranostic and Genomic Applications. Elsevier; 2018.
8. Kahl BS, Yang DT. Follicular Lymphoma: Evolving Therapeutic Strategies. Blood. 2016;127(17):2055-2063.
9. Swerdlow SH, Campo E, Pileri SA, et al. The 2016 Revision of the World Health Organization Classification of Lymphoid Neoplasms. Blood. 2016;127(20):2375-2390.
10. Liu Y, Barta SK. Diffuse Large B-Cell Lymphoma: 2019 Update on Diagnosis, Risk Stratification, and Treatment. Am J Hematol. 2019;94(5):604-616.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "CONFIRM anti-bcl-2 (124) antibody binds to bcl-2 protein in formalin-fixed, paraffin- embedded (FFPE) tissue sections. This antibody can be visualized using ultraView Universal DAB Detection Kit (Cat. No. 760-500 / 05269806001) or OptiView DAB IHC Detection Kit (Cat. No. 760-700 / 06396500001). Refer to the respective method sheet for further information.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "Le CONFIRM anti-bcl-2 (124) Mouse Monoclonal Primary Antibody est destiné à être utilisé en laboratoire pour la détection immunohistochimique qualitative par microscopie optique de la protéine bcl-2 (B-cell lymphoma 2) dans des coupes de tissus fixés au formol et inclus en paraffine (FFPE) colorées sur un appareil BenchMark IHC/ISH.

Ce produit doit être interprété par un anatomopathologiste qualifié, en complément d’examens histologiques, d’informations cliniques pertinentes et de contrôles adaptés.

Cet anticorps est conçu pour une utilisation en diagnostic in vitro (IVD).", "Language": "fr", "Country": "XG", "Code": "Product Purpose" } ] } } ] }