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receipt and when not in use, store at 2-8°C. Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Intended Use", "Value": "Le CONFIRM anti-CD3 (2GV6) Rabbit Monoclonal Primary Antibody est destiné à être utilisé en laboratoire pour la détection immunohistochimique qualitative par microscopie optique de CD3 dans des coupes de tissus fixés au formol et inclus en paraffine colorées sur un appareil BenchMark IHC/ISH. Ce produit doit être interprété par un anatomopathologiste qualifié, en complément d’examens histologiques, d’informations cliniques pertinentes et de contrôles adaptés.

Cet anticorps est conçu pour une utilisation en diagnostic in vitro (IVD).", "Language": "fr", "Country": "XG", "Code": "Intended Use" }, { "Name": "Content", "Value": "CONFIRM anti-CD3 (2GV6) antibody contains sufficient reagent for 50 tests.

One 5 mL dispenser of CONFIRM anti-CD3(2GV6) antibody contains approximately 2 μg of a rabbit monoclonal (2GV6) antibody.
CONFIRM anti-CD3 (2GV6) antibody is diluted in Tris-HCI with carrier protein and ProClin 300, a preservative.

Specific antibody concentration is approximately 0.4 μg/mL. There is no known non- specific antibody reactivity observed in this product.
CONFIRM anti-CD3 (2GV6) antibody is a recombinant rabbit monoclonal antibody produced as purified cell culture supernatant.
Refer to the appropriate VENTANA detection kit method sheet for detailed descriptions of: Principle of the Procedure, Material and Methods, Specimen Collection and Preparation for Analysis, Quality Control Procedures, Troubleshooting, Interpretation of Results, and Limitations.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Background Information", "Value": "CD3 is a multimeric protein complex composed of four distinct polypeptide chains: gamma, delta, epsilon, and zeta.^1,2 Like many commercial CD3 antibodies, CONFIRM anti-CD3 (2GV6) Rabbit Monoclonal Primary Antibody (CONFIRM anti-CD3 (2GV6) antibody) detects the epsilon chain of CD3 which is expressed on T-cells and natural killer (NK)-cells.^1,3 Structurally, CD3 proteins have an N-terminal domain that recognizes foreign antigens, a transmembrane domain,and a cytoplasmic domain, which contains immunoreceptor tyrosine-based activation motifs that propagate signaling cascades.^2,4 Through its cytoplasmic domain, CD3 associates with the T-cell receptor (TCR) and initiates downstream signaling cascades upon antigen recognition.^1,4

On normal tissues, CD3 is expressed on T-cells, Purkinje neurons, and the CD3-epsilon chain is expressed on NK-cells.^1,2 On T-cells, CD3 is initially expressed in the cytoplasm of early thymocytes and is later expressed on the cell membrane of mature T-cells.^1,2 The appearance of CD3 throughout many stages of T-cell maturation makes it an ideal pan T- cell marker and its expression is typically maintained in many T-cell neoplasms.^1,2

However, CD3 expression may occasionally be lost in some T-cell lymphoma subtypes, particularly anaplastic large cell lymphoma (ALCL).³ CD3 is typically not expressed on B- cells, myeloid cells, or their malignant counterparts.^1,2,3

Detection of CD3 by immunohistochemistry (IHC) with the CONFIRM anti-CD3 (2GV6) antibody may be used to aid in the identification of normal and neoplastic T-cells. It may be used as part of a panel of IHC studies. The staining pattern is membranous and/or cytoplasmic.

1. Dabbs DJ. Diagnostic Immunohistochemistry Theranostic and Genomic Applications, 5th Edition. Vol 5. Amsterdam, Netherlands: Elsevier; 2019.
2. Naeim F. Principles of Immunophenotyping. In: Naeim F, Rao PN, Grody WW, eds. Hematopathology: Morphology, Immunophenotype, Cytogenetics, and Molecular Approaches. Cambridge, MA: Academic Press; 2009.
3. Higgins RA, Blankenship JE, Kinney MC. Application of Immunohistochemistry in the Diagnosis of Non-Hodgkin and Hodgkin Lymphoma. Arch Pathol Lab Med. 2008;132(3):441-4", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "CONFIRM anti-CD3 (2GV6) antibody binds to the CD3 protein in formalin-fixed, paraffin- embedded (FFPE) tissue sections. CONFIRM anti-CD3 (2GV6) antibody can be visualized using OptiView DAB IHC Detection Kit (Cat. No. 760-700 / 06396500001) or ultra View Universal DAB Detection Kit (Cat. No. 760-500 / 05269806001). Refer to the respective method sheet for further information.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "Le CONFIRM anti-CD3 (2GV6) Rabbit Monoclonal Primary Antibody est destiné à être utilisé en laboratoire pour la détection immunohistochimique qualitative par microscopie optique de CD3 dans des coupes de tissus fixés au formol et inclus en paraffine colorées sur un appareil BenchMark IHC/ISH. Ce produit doit être interprété par un anatomopathologiste qualifié, en complément d’examens histologiques, d’informations cliniques pertinentes et de contrôles adaptés.

Cet anticorps est conçu pour une utilisation en diagnostic in vitro (IVD).", "Language": "fr", "Country": "XG", "Code": "Product Purpose" } ] } } ] }