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"Name": "Storage Conditions (Product)", "Value": "Upon receipt and when not in use, store at 2-8°C. Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Content", "Value": "Anti-CD43 (L60) antibody contains sufficient reagent for 50 tests.

One 5 mL dispenser of Anti-CD43 (L60) antibody contains approximately 5 μg of a mouse monoclonal antibody.
The antibody is diluted in phosphate buffered saline containing carrier protein and 0.10% ProClin 300, a preservative.
Specific antibody concentration is approximately 1 μg/mL. There is no known non-specific antibody reactivity observed in this product.
Anti-CD43 (L60) antibody is a mouse monoclonal antibody produced as tissue culture supernatant or ascites and purified by affinity chromatography.
Refer to the appropriate VENTANA detection kit method sheet for detailed descriptions of: Principle of the Procedure, Material and Methods, Specimen Collection and Preparation for Analysis, Quality Control Procedures, Troubleshooting, Interpretation of Results, and Limitations.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Intended Use", "Value": "L’Anti-CD43 (L60) Mouse Monoclonal Primary Antibody est destiné à être utilisé en laboratoire pour la détection immunohistochimique qualitative par microscopie optique de CD43 dans les coupes de tissus fixés au formol et inclus en paraffine colorées sur un appareil BenchMark IHC/ISH.
Ce produit doit être interprété par un anatomopathologiste qualifié, en complément d’examens histologiques, d’informations cliniques pertinentes et de contrôles adaptés.

Cet anticorps est conçu pour une utilisation en diagnostic in vitro (IVD).", "Language": "fr", "Country": "XG", "Code": "Intended Use" }, { "Name": "Principle", "Value": "Anti-CD43 (L60) antibody binds to the CD43 protein in formalin-fixed, paraffin-embedded (FFPE) tissue sections. This antibody can be visualized using OptiView DAB IHC Detection Kit (Cat. No. 760-700 / 06396500001), and ultraView Universal DAB Detection Kit (Cat. No. 760-500 / 05269806001). Refer to the respective method sheets for further information.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Background Information", "Value": "CD43, also known as leucosialin or sialophorin, is a transmembrane glycoprotein antigen expressed on the plasma membrane and in the cytoplasm of hematopoietic precursors, cells of myeloid origin except mature erythrocytes, and normal lymphoid cells including T cells, NK cells, precursor B cells, B cells in the gastrointestinal mucosa and plasma cells, but not resting peripheral B cells.^1,2 Western blotting demonstrates heterogeneity of the antigen staining bands in the 110-160 kD range. CD43 is expressed by most T cell lymphomas and some B cell lymphomas.^1-4 Anti-CD43 (L60) Mouse Monoclonal Primary Antibody (Anti-CD43 (L60) antibody) binds specifically to antigens located in the plasma membrane and cytoplasmic regions of normal granulocytes, monocytes, histiocytes, T cells, and some B cells.

CD43 is expressed by most T cell lymphomas.^1-4 When used in a panel with other T- cell markers, the detection of CD43 by immunohistochemistry (IHC) with the Anti-CD43 (L60) antibody may be used as an aid to diagnose T-cell lymphoma.

While normal mature B cells do not express CD43, some mature B-cell neoplasms (e.g. small lymphocytic lymphoma and mantle cell lymphoma) often express it aberrantly.^1-4 Thus, detection of CD43 by IHC with the Anti-CD43 (L60) antibody may also be used as an aid to characterize B-cell lymphoma. CD43 IHC is mostly used to characterize small B-cell lymphomas. CD43 positivity is highest among chronic lymphocytic leukemia/small lymphocytic lymphoma and mantle cell lymphoma, and is almost always absent in follicular lymphoma.^1,2Its use to characterize other B-cell lymphoma subtypes is more limited.^1,2

The staining pattern of this antibody is membranous and cytoplasmic. It may be used as part of a panel of IHC studies.

1. Orazi A, Foucar K, Knowles D, et al. Knowles Neoplastic Hematopathology. Lippincott Williams & Wilkins; 2013.
2. Dabbs DJ. Diagnostic Immunohistochemistry: Theranostic and Genomic Applications. Elsevier; 2018.
3. Strickler JG, Weiss LM, Copenhaver CM, Bindl J, McDaid R, Buck D, Warnke R. Monoclonal antibodies reactive in routinely processed tissue sections of malignant lymphoma, with emphasis on T cell lymphomas. Hum Pathol. Aug; 18(8):808-14, 1987.
4. Stross WP, Warnke RA, Flavell DJ, Flavell SU, Simmons D, Gatter KC, Mason DY. Molecule detected in formalin fixed tissue by antibodies MT1, DF-T1, and L60 (Leu- 22) corresponds to CD43 antigen. J Clin Pathol Sep;42(9):953-61, 1989.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Product Purpose", "Value": "L’Anti-CD43 (L60) Mouse Monoclonal Primary Antibody est destiné à être utilisé en laboratoire pour la détection immunohistochimique qualitative par microscopie optique de CD43 dans les coupes de tissus fixés au formol et inclus en paraffine colorées sur un appareil BenchMark IHC/ISH.
Ce produit doit être interprété par un anatomopathologiste qualifié, en complément d’examens histologiques, d’informations cliniques pertinentes et de contrôles adaptés.

Cet anticorps est conçu pour une utilisation en diagnostic in vitro (IVD).", "Language": "fr", "Country": "XG", "Code": "Product Purpose" } ] } } ] }

anti-CD43 (L60) Mouse Monoclonal Primary Antibody

IVD

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