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"Value": "CD5 is a 67 kDa transmembrane glycoprotein that belongs to the highly conserved scavenger-receptor cysteine-rich superfamily that regulates innate immune responses.1,2 Through its structural domains, CD5 negatively regulates T-cell receptor signaling pathways by inhibiting downstream kinase regulators.1
CD5 is a pan T-cell antigen but is not lineage-specific.1-4 In normal lymphocytes, CD5 is expressed on T-cells and a subset of mature B-cells (B1 cells), but is absent on NK- cells.1,2,3 Some neoplasms derived from T-cells typically retain CD5 expression (e.g. angioimmunoblastic T-cell lymphoma), whereas CD5 expression is generally absent in others (e.g. anaplastic large cell lymphoma, enteropathy-associated T-cell lymphoma, large granular lymphocytic lymphoma).1-4 Additionally, CD5 is aberrantly expressed in select B-cell neoplasms such as mantle celllymphoma, chronic lymphocytic leukemia, and small lymphocytic lymphoma.1-4 Mature B-cell lymphomas such as marginal zone lymphoma, diffuse large B-cell lymphoma, and follicular lymphoma typically do not express CD5.2,3,4
The detection of CD5 by immunohistochemistry (IHC) with the CONFIRM anti-CD5 (SP19) Rabbit Monoclonal Primary Antibody, when evaluated with other markers, may be used to aid in the identification of normal T-cells and aid in the diagnosis of T-cell lymphoma and certain subtypes of B-cell lymphoma. The cellular staining pattern for CONFIRM anti-CD5 (SP19) antibody is membranous or cytoplasmic.
1. Dabbs DJ. Diagnostic Immunohistochemistry Theranostic and Genomic Applications, 5th edition. Vol 5. Amsterdam, Netherlands: Elsevier; 2019.
2. Naeim F. Principles of Immunophenotyping. In: Naeim F, Rao PN, Grody WW, eds. Hematopathology: Morphology, Immunophenotype, Cytogenetics, and Molecular Approaches. Cambridge, MA: Academic Press; 2009.
3. Higgins RA, Blankenship JE, Kinney MC. Application of immunohistochemistry in the diagnosis of non-Hodgkin and Hodgkin lymphoma. Arch Pathol Lab Med. 2008;132(3):441-461.
4. Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edition. Vol 4. Lyon, France: International Agency for Research on Cancer; 2008.",
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One 5 mL dispenser of CONFIRM anti-CD5(SP19) antibody contains approximately 4 μg of a rabbit monoclonal (SP19) antibody.
The antibody is diluted in Tris-HCl with carrier protein and 0.10% ProClin 300, a preservative.
Specific antibody concentration is approximately 0.8 μg/mL. There is no known non- specific antibody reactivity observed in this product.
CONFIRM anti-CD5 (SP19) antibody is arabbit monoclonal antibody produced as cell culture supernatant.
Refer to the appropriate VENTANA detection kit method sheet for detailed descriptions of: Principle of the Procedure, Material and Methods, Specimen Collection and Preparation for Analysis, Quality Control Procedures, Troubleshooting, Interpretation of Results, and Limitations.",
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{
"Name": "Intended Use",
"Value": "L'anticorps CONFIRM anti-CD5 (SP19) Rabbit Monoclonal Primary Antibody de Ventana Medical Systems (Ventana) est dirigé contre le CD5 humain, exprimé sur la membrane plasmatique de pratiquement tous les lymphocytes T humains et dans le sous-ensemble B1a des lymphocytes B humains existant dans les zones folliculaires du manteau, la moelle osseuse et le sang périphérique. La coloration du CD5 est couramment utilisée dans le cadre de plusieurs analyses IHC pour déterminer les sous-types de lymphocytes T et B. Le CD5 peut faciliter l'identification des lymphomes à lymphocytes T et de certains lymphomes à lymphocytes B, notamment le lymphome du manteau. L'anticorps est destiné à la coloration qualitative de coupes de tissus fixés au formol et inclus en paraffine.
L’évaluation doit être effectuée par un pathologiste qualifié conjointement à un examen histologique, aux informations cliniques pertinentes et aux contrôles appropriés.
Cet anticorps est conçu pour être utilisé en diagnostic in vitro (DIV).",
"Language": "fr",
"Country": "XG",
"Code": "Intended Use"
},
{
"Name": "Principle",
"Value": "CONFIRM anti-CD5 (SP19) antibody binds to CD5 glycoprotein in formalin-fixed, paraffin- embedded (FFPE) tissue sections. This antibody can be visualized using ultra View Universal DAB Detection Kit (Cat. No. 760-500 / 05269806001). Refer to the respective method sheet for further information.",
"Language": "en",
"Country": "XG",
"Code": "Principle"
},
{
"Name": "Product Purpose",
"Value": "L'anticorps CONFIRM anti-CD5 (SP19) Rabbit Monoclonal Primary Antibody de Ventana Medical Systems (Ventana) est dirigé contre le CD5 humain, exprimé sur la membrane plasmatique de pratiquement tous les lymphocytes T humains et dans le sous-ensemble B1a des lymphocytes B humains existant dans les zones folliculaires du manteau, la moelle osseuse et le sang périphérique. La coloration du CD5 est couramment utilisée dans le cadre de plusieurs analyses IHC pour déterminer les sous-types de lymphocytes T et B. Le CD5 peut faciliter l'identification des lymphomes à lymphocytes T et de certains lymphomes à lymphocytes B, notamment le lymphome du manteau. L'anticorps est destiné à la coloration qualitative de coupes de tissus fixés au formol et inclus en paraffine.
L’évaluation doit être effectuée par un pathologiste qualifié conjointement à un examen histologique, aux informations cliniques pertinentes et aux contrôles appropriés.
Cet anticorps est conçu pour être utilisé en diagnostic in vitro (DIV).",
"Language": "fr",
"Country": "XG",
"Code": "Product Purpose"
}
]
}
}
]
}
