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"Name": "Storage Conditions (Product)", "Value": "Upon receipt and when not in use, store at 2-8°C. Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Content", "Value": "One dispenser of this antibody contains sufficient prediluted reagent for 50 tests.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Intended Use", "Value": "Cet anticorps est conçu pour être utilisé en diagnostic in vitro (DIV).

L’anticorps anti-CD71 (MRQ-48) de Cell Marque est conçu à l’attention des laboratoires qualifiés afin d’identifier de manière qualitative, par microscopie optique, la présence d’antigènes associés dans des coupes de tissus fixés au formol et inclus en paraffine en utilisant des techniques d’analyses immunohistochimiques (IHC). L’utilisation de cet anticorps est indiquée pour faciliter l’identification des précurseurs érythroïdes dans la moelle osseuse et la détermination de la leucémie myéloïde aiguë et du syndrome myélodysplasique (MDS) dans le contexte d’une gamme d’anticorps, des antécédents cliniques du patient et d’autres tests diagnostiques évalués par un pathologiste qualifié.", "Language": "fr", "Country": "XG", "Code": "Intended Use" }, { "Name": "Background Information", "Value": "CD71, also known as transferrin receptor, is a membrane glycoprotein that mediates the uptake of iron from transferrin for hemoglobin synthesis in erythroid cells.¹ Early erythroid precursors and erythroblasts contain the highest mass of transferrin receptors, and expression is lost as these cells cease hemoglobin synthesis and mature into erythrocytes.¹ Therefore, anti-CD71 is a useful marker for highlighting erythroid precursors in bone marrow specimens.² Increased CD71 expression is also associated with active cell growth including neoplastic tumor growth and may be seen in various carcinomas such as thyroid carcinomas, lung carcinomas, breast carcinomas, hepatocellular carcinomas and colorectal carcinomas.³

1. Ponka P, et al. The transferrin receptor: role in health and disease. Int J Biochem Cell Biol. 1999; 31:1111-37.
2. Marsee DK, et al. CD71 (transferrin receptor): an effective marker for erythroid precursors in bone marrow biopsy specimens. Am J Clin Pathology. 2010; 13:429-35.
3. Chan KT, et al. Overexpression of transferrin receptor CD71 and its tumorigenic properties in esophageal squamous cell carcinoma. Oncol Rep. 2014; 31:1296-304.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "CD71 (MRQ-48) Mouse Monoclonal Antibody (this antibody) may be used as the primary antibody for immunohistochemical staining of formalin-fixed, paraffin-embedded tissue sections. In general, immunohistochemical staining allows the visualization of antigens via the sequential application of a specific antibody (primary antibody) to the antigen, a secondary antibody (link antibody) to the primary antibody, an enzyme complex and a chromogenic substrate with interposed washing steps. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and a coverslip applied. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.

This antibody is optimally diluted to be compatible with VENTANA detection kits and BenchMark IHC/ISH instruments. Refer to the Tables in the Instructions for Use section for recommended staining protocols. Each step in the staining protocol includes incubation for a precise time at a specifi c temperature. At the end of each incubation step, the sections are rinsed by the BenchMark IHC/ISH instruments to stop the reaction and remove unbound material that would hinder the desired reaction in subsequent steps. To minimize evaporation of the aqueous reagents from the specimen-containing slide, a coverslip solution is applied in the slide stainer. For more detailed information on instrument operation, refer to the appropriate BenchMark IHC/ISH instruments Operator’s Manual.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "Cet anticorps est conçu pour être utilisé en diagnostic in vitro (DIV).

L’anticorps anti-CD71 (MRQ-48) de Cell Marque est conçu à l’attention des laboratoires qualifiés afin d’identifier de manière qualitative, par microscopie optique, la présence d’antigènes associés dans des coupes de tissus fixés au formol et inclus en paraffine en utilisant des techniques d’analyses immunohistochimiques (IHC). L’utilisation de cet anticorps est indiquée pour faciliter l’identification des précurseurs érythroïdes dans la moelle osseuse et la détermination de la leucémie myéloïde aiguë et du syndrome myélodysplasique (MDS) dans le contexte d’une gamme d’anticorps, des antécédents cliniques du patient et d’autres tests diagnostiques évalués par un pathologiste qualifié.", "Language": "fr", "Country": "XG", "Code": "Product Purpose" } ] } } ] }