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Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Content", "Value": "Anti-ERG (EPR3864) antibody contains sufficient reagent for 50 tests.

One 5 mL dispenser of anti-ERG (EPR3864) antibody contains approximately 115 μg of a rabbit monoclonal antibody.
The antibody is diluted in a TBS buffer containing carrier protein.
Specific antibody concentration is approximately 23 μg/mL. There is no known nonspecific antibody reactivity observed in this product.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Intended Use", "Value": "L’Anti-ERG (EPR3864) Rabbit Monoclonal Primary Antibody est destiné à être utilisé en laboratoire pour la détection immunohistochimique qualitative par microscopie optique de la protéine ERG de type sauvage et de la forme tronquée de la protéine ERG générée par le réarrangement du gène ERG dans des coupes de tissus fixés au formol et inclus en paraffine colorées sur un appareil BenchMark IHC/ISH.

Ce produit doit être interprété par un anatomopathologiste qualifié, en complément d’examens histologiques, d’informations cliniques pertinentes et de contrôles adaptés.

Cet anticorps est conçu pour une utilisation en diagnostic in vitro (IVD).", "Language": "fr", "Country": "XG", "Code": "Intended Use" }, { "Name": "Background Information", "Value": "The anti-ERG (EPR3864) Rabbit Monoclonal Primary Antibody (anti-ERG (EPR3864) antibody) is a monoclonal antibody produced against the ERG protein encoded by the ETS-related gene, ERG. ERG is a 54kDa member of the E-26 transformation-specific (ETS) family of transcription factors.^1,2 Members of this family are nuclear DNA-binding phosphoproteins that regulate a variety ofcellular processes including proliferation, differentiation, and apoptosis via activation or repression of several target genes. ERG is normally expressed in vascular endothelial cells and lymphocytes. In prostate carcinoma (PCa), the promoter region of TMPRSS2, an androgen-regulated and prostate-specific gene, is fused with the C-terminus of ERG, which results in overexpression of a truncated ERG protein.^3,4Overexpression of truncated ERG is found in 40-70% of PCa, while it is generally absent in benign prostate.^4,5
Several studies have demonstrated the presence of truncated ERG in approximately 50% PCa specimens.^5,6,7,8 Many studies have also shown high concordance between FISH- determined ERG gene rearrangement status and protein overexpression detected by ERG IHC.^{5,9,10,11,12,13,14} Thus, IHC detection of ERG with anti-ERG (EPR3864) antibody may be used as an aid in the identification of prostate adenocarcinomas through the detection of truncated ERG.
The staining pattern for this antibody is nuclear. It may be used as part of a panel of IHC studies.

1. Adamo P, Ladomery MR. The Oncogene ERG: A Key Factor in Prostate Cancer. Oncogene. 2016;35(4):403-414.
2. Gasi Tandefelt D, Boormans J, Hermans K, et al. ETS Fusion Genes in Prostate Cancer. Endocr Relat Cancer. 2014;21(3):R143-152..
3. Hermans KG, Boormans JL, Gasi D, et al. Overexpression of Prostate-Specific TMPRSS2(Exon 0)-ERG Fusion Transcripts Corresponds with Favorable Prognosis of Prostate Cancer. Clin Cancer Res. 2009;15(20):6398-6403.
4. Tomlins SA, Rhodes DR, Perner S, et al. Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer. Science. 2005;310(5748):644-648.
5. van Leenders GJ, Boormans JL, Vissers CJ, et al. Antibody EPR3864 is Specific for ERG Genomic Fusions in Prostate Cancer: Implications for Pathological Practice. Mod Pathol. 2011;24(8):1128-1138.
6. Chaux A, Albadine R, Toubaji A, et al. Immunohistochemistry for ERG Expression as a Surrogate for TMPRSS2-ERG Fusion Detection in Prostatic Adenocarcinomas. Am J Surg Pathol. 2011;35(7):1014-1020.
7. Furusato B, Tan SH, Young D, et al. ERG Oncoprotein Expression in Prostate Cancer: Clonal Progression of ERG-Positive Tumor Cells and Potential for ERG- Based Stratification. Prostate Cancer Prostatic Dis. 2010;13(3):228-237.
8. Park K, Tomlins S, Mudaliar KM, et al. Antibody-based detection of ERG rearrangement-positive prostate cancer. Neoplasia. 2010;12(7):590-598.
9. Falzarano SM, Zhou M, Carver P, et al. ERG Gene Rearrangement Status in Prostate Cancer Detected by Immunohistochemistry. Virchows Archiv. 2011;459(4):441-447.
10. Fisher KW, Zhang S, Wang M, et al. TMPRSS2-ERG Gene Fusion Is Rare Compared to PTEN Deletions in Stage T1a Prostate Cancer. Mol Carcinog. 2017;56(3):814-820.
11. Gopalan A, Leversha MA, Dudas ME, et al. TMPRSS2-ERG Rearrangement in Dominant Anterior Prostatic Tumours: Incidence and Correlation with ERG Immunohistochemistry. Histopathology. 2013;63(2):279-286.
12. Jiang H, Mao X, Huang X, et al. TMPRSS2:ERG Fusion Gene Occurs Less Frequently in Chinese Patients with Prostate Cancer. Tumor Biol. 2016;37(9):12397-12402.
13. Sung J-Y, Jeon HG, Jeong BC, et al. Correlation of ERG Immunohistochemistry with Molecular Detection of TMPRSS2-ERG Gene Fusion. J Clin Pathol. 2016;69(7):586-592.
14. Svensson MA, Perner S, Ohlson A-L, et al. A Comparative Study of ERG Status Assessment on DNA, mRNA, and Protein Levels Using Unique Samples from a Swedish Biopsy Cohort. Applied Immunohistochemistry and Molecular Morphology. 2014;22(2):136-141.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "The anti-ERG (EPR3864) antibody binds to the C-terminus of the ETS transcription regulator ERG in formalin-fixed, paraffin-embedded (FFPE) tissue sections. This antibody can be visualized using ultraView Universal DAB Detection Kit (Cat. No. 760-500 / 05269806001). Refer to the respective method sheet for further information.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "L’Anti-ERG (EPR3864) Rabbit Monoclonal Primary Antibody est destiné à être utilisé en laboratoire pour la détection immunohistochimique qualitative par microscopie optique de la protéine ERG de type sauvage et de la forme tronquée de la protéine ERG générée par le réarrangement du gène ERG dans des coupes de tissus fixés au formol et inclus en paraffine colorées sur un appareil BenchMark IHC/ISH.

Ce produit doit être interprété par un anatomopathologiste qualifié, en complément d’examens histologiques, d’informations cliniques pertinentes et de contrôles adaptés.

Cet anticorps est conçu pour une utilisation en diagnostic in vitro (IVD).", "Language": "fr", "Country": "XG", "Code": "Product Purpose" } ] } } ] }

anti-ERG (EPR3864) Rabbit Monoclonal Primary Antibody

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