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"StructureNodeStatus": "Inactive" } ] } ] }, "ProductSpec": [ { "ProductSpecVariant": { "Chapters": [ { "Name": "Storage Conditions (Product)", "Value": "Upon receipt and when not in use, store at 2-8°C. Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Content", "Value": "One dispenser of this antibody contains sufficient prediluted reagent for 50 tests.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Background Information", "Value": "GATA binding protein 3 or GATA3, is a zinc finger transcription factor and plays an important role in promoting and directing cell proliferation, development, and differentiation in many tissues and cell types.1-4 The human GATA3 gene has been mapped to chromosome 10p15.3 GATA3 expression is primarily seen in breast carcinoma and urothelial carcinoma.1-2 Anti-GATA3 can also be useful in the identification of unknown primary carcinoma when carcinomas of the breast or bladder are a possibility.

1. Higgins JP, et al. Placental S100 (S100P) and GATA3: markers for transitional epithelium and urothelial carcinoma discovered by complementary DNA microarray. Am J Surg Pathol. 2007; 31:673-80.
2. Liu, H, et al. Immunohistochemical evaluation of GATA3 expression in tumors and normal tissues: a useful immunomarker for breast and urothelial carcinomas. Am J Clin Pathol. 2012; 138:57-64.
3. Joulin V, et al. A T-cell specific TCR delta DNA binding protein is a member of the human GATA family. EMBO J. 1991; 10: 1809-16.
4. Labastie M, et al. Structure and expression of the human GATA3 gene. Genomics; 21:1-6.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Intended Use", "Value": "Le GATA3 (L50-823) Mouse Monoclonal Primary Antibody est destiné à un usage en laboratoire pour détecter la protéine GATA3 dans les tissus humains fi xés au formol et enrobés à la paraffi ne colorés dans le cadre de tests d’immunohistochimie (IHC) qualitative sur les instruments d’IHC/ISH BenchMark. Ce produit doit être interprété par un pathologiste compétent en parallèle avec un examen histologique, les informations cliniques pertinentes et les contrôles appropriés. Cet anticorps est destiné à être utilisé aux fins de diagnostic in vitro (IVD).", "Language": "fr", "Country": "XG", "Code": "Intended Use" }, { "Name": "Principle", "Value": "GATA3 (L50-823) Mouse Monoclonal Primary Antibody (this antibody) may be used as the primary antibody for immunohistochemical staining of formalin-fixed, paraffin-embedded tissue sections. In general, immunohistochemical staining allows the visualization of antigens via the sequential application of a specific antibody (primary antibody) to the antigen, a secondary antibody (link antibody) to the primary antibody, an enzyme complex and a chromogenic substrate with interposed washing steps. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and a coverslip applied. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.

This antibody is optimally diluted to be compatible with VENTANA detection kits and BenchMark IHC/ISH instruments. Refer to the Tables in the Instructions for Use section for recommended staining protocols. Each step in the staining protocol includes incubation for a precise time at a specific temperature. At the end of each incubation step, the sections are rinsed by the BenchMark IHC/ISH instruments to stop the reaction and remove unbound material that would hinder the desired reaction in subsequent steps. To minimize evaporation of the aqueous reagents from the specimen-containing slide, a coverslip solution is applied in the slide stainer. For more detailed information on instrument operation, refer to the appropriate BenchMark IHC/ISH instruments Operator’s Manual.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "Le GATA3 (L50-823) Mouse Monoclonal Primary Antibody est destiné à un usage en laboratoire pour détecter la protéine GATA3 dans les tissus humains fi xés au formol et enrobés à la paraffi ne colorés dans le cadre de tests d’immunohistochimie (IHC) qualitative sur les instruments d’IHC/ISH BenchMark. Ce produit doit être interprété par un pathologiste compétent en parallèle avec un examen histologique, les informations cliniques pertinentes et les contrôles appropriés. Cet anticorps est destiné à être utilisé aux fins de diagnostic in vitro (IVD).", "Language": "fr", "Country": "XG", "Code": "Product Purpose" } ] } } ] }

GATA3 (L50-823) Mouse Monoclonal Antibody

IVD For in vitro diagnostic use.
GATA3 (L50-823) Mouse Monoclonal Antibody

Description

Detailed Specifications

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