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"Value": "GATA binding protein 3 or GATA3, is a zinc finger transcription factor and plays an important role in promoting and directing cell proliferation, development, and differentiation in many tissues and cell types.
1-4 The human GATA3 gene has been mapped to chromosome 10p15.
3 GATA3 expression is primarily seen in breast carcinoma and urothelial carcinoma.
1-2 Anti-GATA3 can also be useful in the identification of unknown primary carcinoma when carcinomas of the breast or bladder are a possibility.
1. Higgins JP, et al. Placental S100 (S100P) and GATA3: markers for transitional epithelium and urothelial carcinoma discovered by complementary DNA microarray. Am J Surg Pathol. 2007; 31:673-80.
2. Liu, H, et al. Immunohistochemical evaluation of GATA3 expression in tumors and normal tissues: a useful immunomarker for breast and urothelial carcinomas. Am J Clin Pathol. 2012; 138:57-64.
3. Joulin V, et al. A T-cell specific TCR delta DNA binding protein is a member of the human GATA family. EMBO J. 1991; 10: 1809-16.
4. Labastie M, et al. Structure and expression of the human GATA3 gene. Genomics; 21:1-6.",
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