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"StructureNodeID": "99-00-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "Inactive" } ] } ] }, "ProductSpec": [ { "ProductSpecVariant": { "Chapters": [ { "Name": "Storage Conditions (Product)", "Value": "Upon receipt and when not in use, store at 2-8°C. Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Content", "Value": "One dispenser of this antibody contains sufficient prediluted reagent for 50 tests.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Intended Use", "Value": "Le Glypican-3 (1G12) Mouse Monoclonal Primary Antibody est destiné à un usage en laboratoire pour détecter la protéine glypicane-3 dans les tissus humains fixés au formol et enrobés à la paraffine colorés dans le cadre de tests d’immunohistochimie (IHC) qualitative sur les instruments d’IHC/ISH BenchMark. Ce produit doit être interprété par un pathologiste compétent en parallèle avec un examen histologique, les informations cliniques pertinentes et les contrôles appropriés. Cet anticorps est destiné à être utilisé aux fins de diagnostic in vitro (IVD).", "Language": "fr", "Country": "XG", "Code": "Intended Use" }, { "Name": "Background Information", "Value": "Glypican-3 (GPC3) is a membrane-bound heparin sulfate proteoglycan known to participate in cell growth and differentiation.1 GPC3 expression has been observed in the majority of hepatocellular carcinomas (HCC), but is rarely expressed in non-neoplastic hepatic tissue, making it a useful marker for HCC.1-3 Additionally, this marker is expressed in many yolk sac tumors.1,4

1. Kandil DH, et al. Glypican-3 a novel diagnostic marker for hepatocellular carcinoma and more. Adv Anat Pathol. 2009; 16:125-9.
2. Coston WMP, et al. Distinction of hepatocellular carcinoma from benign hepatic mimickers using Glypican-3 and CD34 immunohistochemistry. Am J Surg Pathol. 2008; 32:433-44.
3. Capurro M, et al. Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma. Gastroenterology. 2003; 125:89-97.
4. Zynger DL, et al. Glypican 3: a novel marker in testicular germ cell tumors. Am J Surg Pathol. 2006; 30:1570-5.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "Glypican-3 (1G12) Mouse Monoclonal Antibody (this antibody) may be used as the primary antibody for immunohistochemical staining of formalin-fixed, paraffin-embedded tissue sections. In general, immunohistochemical staining allows the visualization of antigens via the sequential application of a specific antibody (primary antibody) to the antigen, a secondary antibody (link antibody) to the primary antibody, an enzyme complex and a chromogenic substrate with interposed washing steps. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and a coverslip applied. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.

This antibody is optimally diluted to be compatible with VENTANA detection kits and BenchMark IHC/ISH instruments. Refer to the Tables in the Instructions for Use section for recommended staining protocols. Each step in the staining protocol includes incubation for a precise time at a specifi c temperature. At the end of each incubation step, the sections are rinsed by the BenchMark IHC/ISH instruments to stop the reaction and remove unbound material that would hinder the desired reaction in subsequent steps. To minimize evaporation of the aqueous reagents from the specimen-containing slide, a coverslip solution is applied in the slide stainer. For more detailed information on instrument operation, refer to the appropriate BenchMark IHC/ISH instruments Operator’s Manual.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "Le Glypican-3 (1G12) Mouse Monoclonal Primary Antibody est destiné à un usage en laboratoire pour détecter la protéine glypicane-3 dans les tissus humains fixés au formol et enrobés à la paraffine colorés dans le cadre de tests d’immunohistochimie (IHC) qualitative sur les instruments d’IHC/ISH BenchMark. Ce produit doit être interprété par un pathologiste compétent en parallèle avec un examen histologique, les informations cliniques pertinentes et les contrôles appropriés. Cet anticorps est destiné à être utilisé aux fins de diagnostic in vitro (IVD).", "Language": "fr", "Country": "XG", "Code": "Product Purpose" } ] } } ] }

Glypican-3 (1G12) Mouse Monoclonal Antibody

IVD For in vitro diagnostic use.
Glypican-3 (1G12) Mouse Monoclonal Antibody

Description

Detailed Specifications

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