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"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "073-00",
"StructureGroupPath": "Immunohistochemistry (IHC)",
"StructureGroupName": "Immunohistochemistry (IHC)",
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"NameofStructureSystem": "Applications",
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"IdentifierofStructureSystem": "Pathogens",
"NameofStructureSystem": "Pathogens",
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"NameofStructureSystem": "Disease Areas",
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"ProductSpec": [
{
"ProductSpecVariant": {
"Chapters": [
{
"Name": "Storage Conditions (Product)",
"Value": "Upon receipt and when not in use, store at 2-8°C. Do not freeze.",
"Language": "en",
"Country": "XG",
"Code": "Storage Conditions (Product)"
},
{
"Name": "Content",
"Value": "Anti-p504s (SP116) Primary Antibody contains sufficient reagent for 50 tests.
One 5 mL dispenser of anti-p504s (SP116) Primary Antibody contains approximately 1.5 μg of a rabbit monoclonal antibody.
The antibody is diluted in 0.05M Tris-HCL with 1% carrier protein and ProClin 300, a preservative. Total protein concentration of the reagent is approximately 3 mg/mL.
Specific antibody concentration is approximately 0.3 μg/mL. There is no known non-specific antibody reactivity observed in this product.",
"Language": "en",
"Country": "XG",
"Code": "Content"
},
{
"Name": "Intended Use",
"Value": "L’Anti-p504s (SP116) Rabbit Monoclonal Primary Antibody est destiné à être utilisé en laboratoire pour la détection immunohistochimique qualitative par microscopie optique de l’α-méthylacyl-CoA racémase (AMACR, également nommée p504s) dans des coupes de tissus fixés au formol et inclus en paraffine colorées sur un appareil BenchMark IHC/ISH.
Ce produit doit être interprété par un anatomopathologiste qualifié, en complément d’examens histologiques, d’informations cliniques pertinentes et de contrôles adaptés.
Cet anticorps est conçu pour une utilisation en diagnostic in vitro (DIV).",
"Language": "fr",
"Country": "XG",
"Code": "Intended Use"
},
{
"Name": "Background Information",
"Value": "The anti-p504s (SP116) Rabbit Monoclonal Primary Antibody (anti-p504s (SP116) Primary Antibody) is a monoclonal antibody produced against the p504s protein. p504s is a 42kDa protein located in mitochondria and peroxisomes. It plays a role in the β-oxidation of branched chain fatty acids.1 While normal and benign prostate tissues express low levels of p504s, it is markedly overexpressed in most prostate carcinomas (PCa), including some atypical forms of PCa.2
First reported in 2000 to be overexpressed in PCa,3 many subsequent studies have reported high sensitivity and specificity values for p504s in PCa and high-grade prostatic intraepithelial neoplasia (HGPIN).4,5,6,7 Furthermore, several articles report that when p504s is used with antibodies for basal cell markers like high molecular weight cytokeratin (HMWCK) or p63, the differential staining patterns among benign glands, benign mimickers of PCa like HGPINs, and prostate carcinoma, improves diagnostic accuracy.2,4,5,7,8,9,10 The differential staining pattern is particularly useful in the workup of clinically atypical prostate cases, as supported by numerous published reports.10,11,12,13,14,15
Note that p504s can be present in normal, atypical, and malignant prostate tissues to varying degrees, and the threshold for interpretation of p504s staining as positive is subjective. The recommended practice is to interpret p504s staining results in conjunction with basal cell markers and morphological features. Immunohistochemical detection of p504s with anti- p504s (SP116) Primary Antibody may be used as a complementary IHC stain with Ventana Basal Cell Cocktail (34βE12 + p63) to assist in distinguishing morphologically difficult prostate tissue as benign, atypical or cancerous. (Note: Antibody clone 34βE12 detects HMWCK, a basal cell marker.)
The staining pattern for this antibody is cytoplasmic. It may be used as part of a panel of IHC studies.
1. Dabbs DJ. Diagnostic Immunohistochemistry: Theranostic and Genomic Applications. Elsevier; 2018.
2. Zhou M, Jiang Z, Epstein JI. Expression and diagnostic utility of alpha-methylacyl- CoA-racemase (P504S) in foamy gland and pseudohyperplastic prostate cancer. Am J Surg Pathol. 2003;27(6):772-778.
3. Xu JC, Stolk JA, Zhang XQ, et al. Identification of Differentially Expressed Genes in Human Prostate Cancer Using Subtraction and Microarray. Cancer Res. 2000;60(6):1677-1682.
4. Luo J, Zha S, Gage WR, et al. Alpha-Methylacyl-Coa Racemase: A New Molecular Marker for Prostate Cancer. Cancer Res. 2002;62(8):2220-2226.
5. Magi-Galluzzi C, Luo J, Isaacs WB, et al. Alpha-Methylacyl-Coa Racemase: A Variably Sensitive Immunohistochemical Marker for the Diagnosis of Small Prostate Cancer Foci on Needle Biopsy. Am J Surg Pathol. 2003;27(8):1128-1133.
6. Rubin MA, Zhou M, Dhanasekaran SM, et al. Alpha-Methylacyl Coenzyme a Racemase as a Tissue Biomarker for Prostate Cancer. Jama-J Am Med Assoc. 2002;287(13):1662-1670.
7. Jiang Z, Woda BA, Rock KL, et al. P504S: a new molecular marker for the detection of prostate carcinoma. Am J Surg Pathol. 2001;25(11):1397-1404.
8. Beach R, Gown AM, De Peralta-Venturina MN, et al. P504s Immunohistochemical Detection in 405 Prostatic Specimens Including 376 18-Gauge Needle Biopsies. Am J Surg Pathol. 2002;26(12):1588-1596.
9. Dema ALC, Taban SM, Lazar E, et al. Alpha-Methylacyl-Coa-Racemase Expression in Variants and Unusual Patterns of Prostate Carcinoma. Rev Romana Med Lab. 2011;19(4):319-331.
10. Jiang Z, Wu CL, Woda BA, et al. P504s/Alpha-Methylacyl-Coa Racemase: A Useful Marker for Diagnosis of Small Foci of Prostatic Carcinoma on Needle Biopsy. Am J Surg Pathol. 2002;26(9):1169-1174.
11. Jiang Z, Iczkowski KA, Woda BA, et al. P504s Immunostaining Boosts Diagnostic Resolution of “Suspicious” Foci in Prostatic Needle Biopsy Specimens. Am J Clin Pathol. 2004;121(1):99-107
12. Kunju LP, Rubin MA, Chinnaiyan AM, et al. Diagnostic Usefulness of Monoclonal Antibody P504s in the Workup of Atypical Prostatic Glandular Proliferations. Am J Clin Pathol. 2003;120(5):737-745.
13. Molinie V, Fromont G, Sibony M, et al. Diagnostic Utility of a P63/Alpha-Methyl-Coa- Racemase (P504s) Cocktail in Atypical Foci in the Prostate. Mod Pathol. 2004;17(10):1180-1190.
14. Sanguedolce F, Cormio A, Musci G, et al. Typing the Atypical: Diagnostic Issues and Predictive Markers in Suspicious Prostate Lesions. Crit Rev Clin Lab Sci. 2017;54(5):309-325.
15. Zhou M, Aydin H, Kanane H, et al. How Often Does Alpha-Methylacyl-Coa- Racemase Contribute to Resolving an Atypical Diagnosis on Prostate Needle Biopsy Beyond That Provided by Basal Cell Markers? Am J Surg Pathol. 2004;28(2):239-243.",
"Language": "en",
"Country": "XG",
"Code": "Background Information"
},
{
"Name": "Principle",
"Value": "Anti-p504s (SP116) Primary Antibody is a rabbit monoclonal antibody produced against recombinant human p504s protein. Anti-p504s (SP116) Primary Antibody binds to the p504s protein in formalin-fixed, paraffin-embedded (FFPE) tissue sections and exhibits a granular cytoplasmic staining pattern. This antibody can be visualized using ultraView Universal Alkaline Phosphatase Red Detection Kit (Cat. No. 760-501 / 05269814001) or as a dual stain in conjunction with VENTANA Basal Cell Cocktail (34βE12+p63) (Cat. No. 790-4536 / 06364497001) using ultraView Universal DAB Detection Kit (Cat. No. 760-500 / 05269806001). Refer to the respective method sheet for further information.
In addition to staining with anti-p504s (SP116) Primary Antibody, a second slide should be stained with the appropriate negative control reagent.",
"Language": "en",
"Country": "XG",
"Code": "Principle"
},
{
"Name": "Product Purpose",
"Value": "L’Anti-p504s (SP116) Rabbit Monoclonal Primary Antibody est destiné à être utilisé en laboratoire pour la détection immunohistochimique qualitative par microscopie optique de l’α-méthylacyl-CoA racémase (AMACR, également nommée p504s) dans des coupes de tissus fixés au formol et inclus en paraffine colorées sur un appareil BenchMark IHC/ISH.
Ce produit doit être interprété par un anatomopathologiste qualifié, en complément d’examens histologiques, d’informations cliniques pertinentes et de contrôles adaptés.
Cet anticorps est conçu pour une utilisation en diagnostic in vitro (DIV).",
"Language": "fr",
"Country": "XG",
"Code": "Product Purpose"
}
]
}
}
]
}
