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One 5 mL dispenser of Anti-p53 (Bp53-11) antibody contains approximately 12.5 µg of a mouse monoclonal antibody directed against an epitope present on the human p53 antibody.
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Refer to the appropriate VENTANA detection kit method sheet for detailed descriptions of:
Principle of the Procedure, Material and Methods, Specimen Collection and Preparation
for Analysis, Quality Control Procedures, Troubleshooting, Interpretation of Results, and
Limitations.",
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{
"Name": "Intended Use",
"Value": "L’Anti-p53 (Bp53-11) Primary Antibody est destiné à être utilisé en laboratoire pour la détection immunohistochimique qualitative par microscopie optique de la protéine p53 dans les coupes de tissus fixés au formol et inclus en paraffine colorées sur un appareil BenchMark IHC/ISH. Ce produit doit être interprété par un anatomopathologiste qualifié, en complément d’examens histologiques, d’informations cliniques pertinentes et de contrôles adaptés.
Cet anticorps est conçu pour une utilisation en diagnostic in vitro (DIV).",
"Language": "fr",
"Country": "XG",
"Code": "Intended Use"
},
{
"Name": "Background Information",
"Value": "Anti-p53 (Bp53-11) Primary Antibody (Anti-p53 (Bp53-11) antibody) recognizes tumor protein p53 (TP53) also known as p53. The p53 protein is a 43.7 kDa DNA binding protein comprised of 393 amino acids. It consists of six domains: the transcription activation domain I (TAD 1); the transcription activation domain II (TAD II); the proline-rich region (PRD); the central core domain, which includes the DNA binding domain (DBD); the tetramerization domain (TD), and the C-terminal basic domain (BD).1 Full-length p53 can reversibly form tetramers via the TD.2 Tetramer formation of p53 is essential for site- specific DNA binding, posttranslational modifications, and protein-protein interactions.2
The p53 protein plays a central role in maintaining genomic integrity by halting the cell cycle upon genomic stress and hindering proliferation of cells with damaged DNA.2,3,4,5 The p53 protein is maintained at very low levels in unstimulated cells; however, in response to various stimuli such as DNA damage, nutrient deprivation, ribonucleotide depletion, hypoxia, oxidative stress, and hyper-proliferative signals, p53 becomes stabilized and accumulates in the cells.3 Once activated, p53 mediates changes in gene expression and promotes cell cycle arrest, apoptosis, and DNA repair.3,6 Therefore, inactivation of p53 can result in proliferation and transformation of compromised cells.5
The detection of wild type and mutant p53 protein by immunohistochemistry (IHC) with the Anti-p53 (Bp53-11) antibody may be used to provide ancillary information regarding the accumulation of p53, which is associated with cell cycle dysregulation and loss of tumor suppression. It may be used as part of a panel of IHC studies. The staining pattern is nuclear.
1. Kim S, An SS. Role of P53 Isoforms and Aggregations in Cancer. Medicine (Baltimore). 2016;95(26):e3993.
2. Kamada R, Toguchi Y, Nomura T, et al. Tetramer Formation of Tumor Suppressor Protein P53: Structure, Function, and Applications. Biopolymers. 2016;106(4):598- 612.
3. Vieler M, Sanyal S. P53 Isoforms and Their Implications in Cancer. Cancers (Basel). 2018;10(9).
4. Harris SL, Levine AJ. The P53 Pathway: Positive and Negative Feedback Loops. Oncogene. 2005;24(17):2899-2908.
5. Powell DJ, Hrstka R, Candeias M, et al. Stress-Dependent Changes in the Properties of P53 Complexes by the Alternative Translation Product P53/47. Cell Cycle. 2008;7(7):950-959.
6. Goh AM, Coffill CR, Lane DP. The Role of Mutant P53 in Human Cancer. J Pathol. 2011;223(2):116-126.",
"Language": "en",
"Country": "XG",
"Code": "Background Information"
},
{
"Name": "Principle",
"Value": "Anti-p53 (Bp53-11) antibody is a mouse monoclonal antibody directed against the p53 protein. Anti-p53 (Bp53-11) antibody binds to the p53 protein in formalin-fixed, paraffin- embedded (FFPE) tissue sections. This antibody can be visualized using ultraView Universal DAB Detection Kit (Cat. No. 760-500 / 05269806001) or OptiView DAB IHC Detection Kit (Cat. No. 760-700 / 06396500001) on a BenchMark IHC/ISH instrument.
Refer to the respective method sheet for further information.",
"Language": "en",
"Country": "XG",
"Code": "Principle"
},
{
"Name": "Product Purpose",
"Value": "L’Anti-p53 (Bp53-11) Primary Antibody est destiné à être utilisé en laboratoire pour la détection immunohistochimique qualitative par microscopie optique de la protéine p53 dans les coupes de tissus fixés au formol et inclus en paraffine colorées sur un appareil BenchMark IHC/ISH. Ce produit doit être interprété par un anatomopathologiste qualifié, en complément d’examens histologiques, d’informations cliniques pertinentes et de contrôles adaptés.
Cet anticorps est conçu pour une utilisation en diagnostic in vitro (DIV).",
"Language": "fr",
"Country": "XG",
"Code": "Product Purpose"
}
]
}
}
]
}
