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"Value": "Le VENTANA anti-p63 (4A4) Mouse Monoclonal Primary Antibody est destiné à être utilisé en laboratoire pour la détection immunohistochimique qualitative par microscopie optique de la protéine p63 dans des coupes de tissus fixés au formol et inclus en paraffine colorées sur un appareil BenchMark IHC/ISH.
Ce produit doit être interprété par un anatomopathologiste qualifié, en complément d’examens histologiques, d’informations cliniques pertinentes et de contrôles adaptés.
Cet anticorps est conçu pour une utilisation en diagnostic in vitro (IVD).",
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"Value": "VENTANA anti-p63 (4A4) antibody contains sufficient reagent for 50 tests.
One 5 mL dispenser of VENTANA anti-p63 (4A4) antibody contains approximately 0.7 μg of a mouse monoclonal antibody.
The antibody is diluted in Tris-HCl with carrier protein and 0.10% ProClin 300, a preservative.
Specific antibody concentration is approximately 0.14 μg/mL. There is no known non-specific antibody reactivity observed in this product.
VENTANA anti-p63 (4A4) is a monoclonal antibody produced as cell culture supernatant material.
Refer to the appropriate VENTANA detection kit method sheets for detailed descriptions of: Principle of the Procedure, Material and Methods, Specimen Collection and Preparation for Analysis, Quality Control Procedures, Troubleshooting, Interpretation of Results, and Limitations.",
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"Value": "VENTANA anti-p63 (4A4) Mouse Monoclonal Primary Antibody (VENTANA anti-p63 (4A4) antibody) is a mouse monoclonal antibody produced against the p63 protein. The human tumor protein 63 (TP63, p63) is a 77 kDa protein localized to the cellular nucleus and member of the p53 family of transcription factors.1 The p63 protein is expressed in the basal or progenitor cells of epithelial tissues and glandular structures including the prostate, breast, and bronchi.2,3,4 In the prostate, p63 is expressed in the basal cells of almost all normal and benign glands but is not present in the neuroendocrine or luminal secretory cells.5 In breast, p63 is expressed in the basal myoepithelial cell (MEC) layer in normal tissue as well as in benign lesions.4 Invasive lesions that evolve from and involve the prostate or breast can disrupt and eventually breach the basal membrane thus eliminating the presence of prostatic basal cells or breast MECs.4,6
The immunohistochemistry (IHC)-based detection of p63 in prostatic basal cells is a feature of normal and benign processes and the absence of p63 is indicative of carcinoma of the prostate.6 The detection of p63 in prostatic basal cells with VENTANA anti-p63 (4A4) antibody may be used to aid in the differentiation of benign and malignant prostate lesions. The detection of p63 in breast MECs is a hallmark of non-invasive processes and the absence of p63 is indicative of invasive neoplasms.7,8 The detection of p63 in breast MECs with VENTANA anti-p63 (4A4) antibody may be used to aid in distinguishing invasive from non-invasive breast neoplasms.
In lung, p63 is expressed in the basal cell compartment.3 It has been speculated that squamous cell carcinoma (SCCA) of the lung originates from the basal compartment.9 Thus, the overexpression of p63 in non-small cell lung cancer (NSCLC) can be an indicator of malignant squamous differentiation.10,11,12 The detection of p63 with VENTANA anti-p63 (4A4) antibody may be used as a marker of squamous differentiation to aid in the distinction between pulmonary SCCA and pulmonary adenocarcinoma (ADC). This antibody may be used as part of a panel of IHC studies.
1. Yang A, Kaghad M, Wang Y, et al. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell. 1998;2:305-16
2. Yang A, Schweitzer R, Sun D, et al. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature. 1999;398:714-718.
3. Nobre AR, Albergaria A, Schmitt F. P40: A P63 Isoform Useful for Lung Cancer Diagnosis - a Review of the Physiological and Pathological Role of P63. Acta Cytol. 2013;57(1):1-8.
4. Barbareschi M, Pecciarini L, Cangi MG, et al. P63, a P53 Homologue, Is a Selective Nuclear Marker of Myoepithelial Cells of the Human Breast. Am J Surg Pathol. 2001;25(8):1054-1060.
5. Signoretti S, Waltregny D, Dilks J, et al. p63 is a prostate basal cell marker and is required for prostate development. Am J Pathol. 2000;157:1769-1775.
6. Epstein JI, Egevad L, Humphrey PA, et al. Best Practices Recommendations in the Application of Immunohistochemistry in the Prostate: Report from the International Society of Urologic Pathology Consensus Conference. Am J Surg Pathol. 2014;38(8):e6-e19.
7. Zhao L, Yang X, Khan A, et al. Diagnostic Role of Immunohistochemistry in the Evaluation of Breast Pathology Specimens. Arch Pathol Lab Med. 2014;138(1):16- 24.
8. Dewar R, Fadare O, Gilmore H, et al. Best Practices in Diagnostic Immunohistochemistry: Myoepithelial Markers in Breast Pathology. Arch Pathol Lab Med. 2011;135(4):422-429.
9. Hanna JM, Onaitis MW. Cell of Origin of Lung Cancer. J Carcinog. 2013;12:6.
10. Warth A, Muley T, Herpel E, et al. Large-Scale Comparative Analyses of Immunomarkers for Diagnostic Subtyping of Non-Small-Cell Lung Cancer Biopsies. Histopathology. 2012;61(6):1017-1025.
11. Rekhtman N, Ang DC, Sima CS, et al. Immunohistochemical Algorithm for Differentiation of Lung Adenocarcinoma and Squamous Cell Carcinoma Based on Large Series of Whole-Tissue Sections with Validation in Small Specimens. Mod Pathol. 2011;24(10):1348-1359.
12. Tacha D, Yu C, Bremer R, et al. A 6-antibody panel for the classification of lung adenocarcinoma versus squamous cell carcinoma. Appl Immunohistochem Mol Morphol. 2012;20:201-207.",
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"Name": "Product Purpose",
"Value": "Le VENTANA anti-p63 (4A4) Mouse Monoclonal Primary Antibody est destiné à être utilisé en laboratoire pour la détection immunohistochimique qualitative par microscopie optique de la protéine p63 dans des coupes de tissus fixés au formol et inclus en paraffine colorées sur un appareil BenchMark IHC/ISH.
Ce produit doit être interprété par un anatomopathologiste qualifié, en complément d’examens histologiques, d’informations cliniques pertinentes et de contrôles adaptés.
Cet anticorps est conçu pour une utilisation en diagnostic in vitro (IVD).",
"Language": "fr",
"Country": "XG",
"Code": "Product Purpose"
}
]
}
}
]
}
