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"Name": "Storage Conditions (Product)",
"Value": "Upon receipt and when not in use, store at 2-8°C. Do not freeze.",
"Language": "en",
"Country": "XG",
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"Value": "Le PGP 9.5 Rabbit Polyclonal Primary Antibody est destiné à un usage en laboratoire pour détecter la enzyme PGP9.5 (UCH-L1) dans les tissus fixés au formol et enrobés à la paraffine, colorés sur les instruments VENTANA BenchMark IHC/ISH. Ce produit doit être interprété par un pathologiste compétent en parallèle avec un examen histologique, les informations cliniques pertinentes et les contrôles appropriés. Cet anticorps est destiné à être utilisé aux fins de diagnostic
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"Name": "Background Information",
"Value": "Protein gene product 9.5 (PGP 9.5), also known as ubiquitin carboxyl-terminal hydrolase-1 (UCHL-1), is a 27 kDa protein originally isolated from whole brain extracts.
1 Although PGP 9.5 expression in normal tissues was originally felt to be strictly confined to neurons and neuroendocrine cells,
2 it has been subsequently documented in distal renal tubular epithelium, spermatogonia, Leydig cells, oocytes, melanocytes, prostatic secretory epithelium, ejaculatory duct cells, epididymis, mammary epithelial cells, Merkel cells, and dermal fibroblasts.
1 A plethora of mesenchymal neoplasms have demonstrated PGP 9.5 expression.
1,3,41. Campbell LK, et al. Protein gene product 9.5 (PGP 9.5) is not a specific marker of neural and nerve sheath tumors: an immunohistochemical study of 95 mesenchymal neoplasms. Mod Pathol. 2003; 16:963-9.
2. Bassotti G, et al. Interstitial cells of Cajal, enteric nerves, and glial cells in colonic diverticular disease. J Clin Pathol. 2005; 58:973-7.
3. Mahalingam M, et al. Expression of PGP 9.5 in granular cell nerve sheath tumors: and immunohistochemical study of six cases. J Cutan Pathol. 2001; 28:282-6.
4. Mahalingam M, et al. Multiple cellular neurothekeomas—a case report and review on the role of immunohistochemistry as a histo-logic adjunct. J Cutan Pathol. 2006; 33:51-6.",
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This antibody is optimally diluted to be compatible with VENTANA detection kits and BenchMark IHC/ISH instruments. Refer to the Tables in the Instructions for Use section for recommended staining protocols. Each step in the staining protocol includes incubation for a precise time at a specifi c temperature. At the end of each incubation step, the sections are rinsed by the BenchMark IHC/ISH instruments to stop the reaction and remove unbound material that would hinder the desired reaction in subsequent steps. To minimize evaporation of the aqueous reagents from the specimen-containing slide, a coverslip solution is applied in the slide stainer. For more detailed information on instrument operation, refer to the appropriate BenchMark IHC/ISH instruments Operator’s Manual.",
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