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"Value": "The SOX-2 protein is part of large family of transcription factors that function in regulating a variety of different processes during embryonic development and maintaining pluripotency of stem cells including germ cells and neural cells.
1-4 Dysregulation of SOX-2 can lead to malignancies in many organ systems, specifically lung carcinomas, non-seminomatous germ cell tumors, neuroendocrine cancers and neuroglial tumors.
1-41. Sholl LM, et al. SOX2 expression in pulmonary non-small cell and neuroendocrine carcinomas. Appl Immunohistochem Mol Morphol. 2010; 18:55-61.
2. Gopalan A, et al. Testicular mixed germ cell tumors: a morphological and immunohistochemical study using stem cell markers, OCT3/4, SOX2 and GDF3, with emphasis on morphologically difficult-to-classify areas. Mod Pathol. 2009; 22:1066-74.
3. Maier S, et al. SOX 2 amplification is a common event in squamous cell carcinomas of different organ sites. Human Pathol. 2011; 42:1078-88.
4. Phi JH, et al. Sox 2 expression in brain tumors: a reflection of the neuroglial differentiation pathway. Am J Surg Pathol. 2008; 32:103-12.",
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