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Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Content", "Value": "One dispenser of this antibody contains sufficient prediluted reagent for 50 tests.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Background Information", "Value": "The SOX-2 protein is part of large family of transcription factors that function in regulating a variety of different processes during embryonic development and maintaining pluripotency of stem cells including germ cells and neural cells.1-4 Dysregulation of SOX-2 can lead to malignancies in many organ systems, specifically lung carcinomas, non-seminomatous germ cell tumors, neuroendocrine cancers and neuroglial tumors.1-4

1. Sholl LM, et al. SOX2 expression in pulmonary non-small cell and neuroendocrine carcinomas. Appl Immunohistochem Mol Morphol. 2010; 18:55-61.
2. Gopalan A, et al. Testicular mixed germ cell tumors: a morphological and immunohistochemical study using stem cell markers, OCT3/4, SOX2 and GDF3, with emphasis on morphologically difficult-to-classify areas. Mod Pathol. 2009; 22:1066-74.
3. Maier S, et al. SOX 2 amplification is a common event in squamous cell carcinomas of different organ sites. Human Pathol. 2011; 42:1078-88.
4. Phi JH, et al. Sox 2 expression in brain tumors: a reflection of the neuroglial differentiation pathway. Am J Surg Pathol. 2008; 32:103-12.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Intended Use", "Value": "L’anticorps primaire monoclonal de lapin de la SOX-2 (SP76) est destiné à l’usage en laboratoire pour la détection de la protéine SOX-2 dans du tissu fixé au formaldéhyde, inclus dans la paraffine, coloré sur les instruments (IHC/ISH) VENTANA BenchMark. Ce produit doit être interprété par un pathologiste compétent en parallèle avec un examen histologique, les informations cliniques pertinentes et les contrôles appropriés. Cet anticorps est destiné à être utilisé aux fins de diagnostic in vitro (IVD).", "Language": "fr", "Country": "XG", "Code": "Intended Use" }, { "Name": "Principle", "Value": "anti-SOX-2 (SP76) Rabbit Monoclonal Primary Antibody (this antibody) may be used as the primary antibody for immunohistochemical staining of formalin-fixed, paraffin-embedded tissue sections. In general, immunohistochemical staining allows the visualization of antigens via the sequential application of a specific antibody (primary antibody) to the antigen, a secondary antibody (link antibody) to the primary antibody, an enzyme complex and a chromogenic substrate with interposed washing steps. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and a coverslip applied. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.

This antibody is optimally diluted to be compatible with VENTANA detection kits and BenchMark IHC/ISH instruments. Refer to the Tables in the Instructions for Use section for recommended staining protocols. Each step in the staining protocol includes incubation for a precise time at a specifi c temperature. At the end of each incubation step, the sections are rinsed by the BenchMark IHC/ISH instruments to stop the reaction and remove unbound material that would hinder the desired reaction in subsequent steps. To minimize evaporation of the aqueous reagents from the specimen-containing slide, a coverslip solution is applied in the slide stainer. For more detailed information on instrument operation, refer to the appropriate BenchMark IHC/ISH instruments Operator’s Manual.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "L’anticorps primaire monoclonal de lapin de la SOX-2 (SP76) est destiné à l’usage en laboratoire pour la détection de la protéine SOX-2 dans du tissu fixé au formaldéhyde, inclus dans la paraffine, coloré sur les instruments (IHC/ISH) VENTANA BenchMark. Ce produit doit être interprété par un pathologiste compétent en parallèle avec un examen histologique, les informations cliniques pertinentes et les contrôles appropriés. Cet anticorps est destiné à être utilisé aux fins de diagnostic in vitro (IVD).", "Language": "fr", "Country": "XG", "Code": "Product Purpose" } ] } } ] }

anti-SOX-2 (SP76) Rabbit Monoclonal Primary Antibody

IVD For in vitro diagnostic use.
anti-SOX-2 (SP76) Rabbit Monoclonal Primary Antibody

Description

Detailed Specifications

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