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"StructureGroupName": "BenchMark", "StructureNodeStatus": "Active" } ] } ] }, "ProductSpec": [ { "ProductSpecVariant": { "Chapters": [ { "Name": "Storage Conditions (Product)", "Value": "Store at 2-8ºC. Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Intended Use", "Value": "Le CONFIRM anti-Synaptophysin (SP11) Rabbit Monoclonal Primary Antibody est destiné à être utilisé en laboratoire pour la détection immunohistochimique qualitative par microscopie optique de la synaptophysine dans des coupes de tissus fixés au formol et inclus en paraffine colorées sur un appareil BenchMark IHC/ISH.

Ce produit doit être interprété par un anatomopathologiste qualifié, en complément d’examens histologiques, d’informations cliniques pertinentes et de contrôles adaptés.

Cet anticorps est conçu pour une utilisation en diagnostic in vitro (IVD).", "Language": "fr", "Country": "XG", "Code": "Intended Use" }, { "Name": "Content", "Value": "CONFIRM anti-Synaptophysin (SP11) antibody contains sufficient reagent for 50 tests.

One 5 mL dispenser of CONFIRM anti-Synaptophysin (SP11) antibody contains approximately 0.3 μg of a rabbit monoclonal antibody.

The antibody is diluted in phosphate buffer with carrier protein and 0.05% ProClin 300, a preservative.

Specific antibody concentration is approximately 0.06 μg/mL. There is no known non-specific antibody reactivity observed in this product.

CONFIRM anti-Synaptophysin (SP11) antibody is a recombinant rabbit monoclonal antibody produced as purified cell culture supernatant.

Refer to the appropriate VENTANA detection kit method sheet for detailed descriptions of: Principle of the Procedure, Material and Methods, Specimen Collection and Preparation for Analysis, Quality Control Procedures, Troubleshooting, Interpretation of Results, and Limitations.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Background Information", "Value": "Synaptophysin is a 38 kilodalton integral membrane glycoprotein expressed in presynaptic vesicles of neurons.1 Synaptophysin is a general marker for neuroendocrine cells, as well as the tumors that are derived from them.2 Neuroendocrine tumors originate in specialized cells of the body's neuroendocrine system and can arise in various anatomical locations.3 The diagnosis of a suspected neuroendocrine tumor begins by confirming neuroendocrine differentiation, using an immunohistochemistry (IHC) based panel of general neuroendocrine markers.2,4 Clinical guidelines and best practice articles recommend the use of synaptophysin IHC as part of a panel with other neuroendocrine markers, to aid in the diagnosis of neuroendocrine tumors.2,5,6,7 The detection of synaptophysin by IHC using CONFIRM anti-Synaptophysin (SP11) Rabbit Monoclonal Primary Antibody (CONFIRM anti-Synaptophysin (SP11) antibody) may be used to aid in the diagnosis of neuroendocrine tumors.

1. Wiedenmann B, Franke WW. Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles. Cell 41(3): 1017-1028, 1985.
2. Bellizzi AM. Immunohistochemistry in the Diagnosis and Classification of Neuroendocrine Neoplasms: What Can Brown Do for You? Human Pathology. 2020;96:8-33.
3. Rindi G, Klimstra DS, Abedi-Ardekani B, et al. A Common Classification Framework for Neuroendocrine Neoplasms: An International Agency for Research on Cancer (IARC) and World Health Organization (WHO) Expert Consensus Proposal. Mod Pathol. 2018;31(12):1770-1786.
4. Duan K, Mete O. Algorithmic Approach to Neuroendocrine Tumors in Targeted Biopsies: Practical Applications of Immunohistochemical Markers. Cancer Cytopathol. 2016;124(12):871-884.
5. Kyriakopoulos G, Mavroeidi V, Chatzellis E, et al. Histopathological, Immunohistochemical, Genetic and Molecular Markers of Neuroendocrine Neoplasms. Ann Transl Med. 2018;6(12):252.
6. Pavel M, Oberg K, Falconi M, et al. Gastroenteropancreatic Neuroendocrine Neoplasms: ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-Up. Ann Oncol. 2020;31(7):844-860.
7. Caplin ME, Baudin E, Ferolla P, et al. Pulmonary Neuroendocrine (Carcinoid) Tumors: European Neuroendocrine Tumor Society Expert Consensus and Recommendations for Best Practice for Typical and Atypical Pulmonary Carcinoids. Ann Oncol. 2015;26(8):1604-1620.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "CONFIRM anti-Synaptophysin (SP11) antibody binds to the Synaptophysin glycoprotein in in formalin-fixed, paraffin-embedded (FFPE) tissue sections. This antibody can be visualized using ultraView Universal DAB Detection Kit (Cat. No. 760-500 / 05269806001) or OptiView DAB IHC Detection Kit (Cat. No. 760-700 / 06396500001). Refer to the respective method sheet for further information.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "Le CONFIRM anti-Synaptophysin (SP11) Rabbit Monoclonal Primary Antibody est destiné à être utilisé en laboratoire pour la détection immunohistochimique qualitative par microscopie optique de la synaptophysine dans des coupes de tissus fixés au formol et inclus en paraffine colorées sur un appareil BenchMark IHC/ISH.

Ce produit doit être interprété par un anatomopathologiste qualifié, en complément d’examens histologiques, d’informations cliniques pertinentes et de contrôles adaptés.

Cet anticorps est conçu pour une utilisation en diagnostic in vitro (IVD).", "Language": "fr", "Country": "XG", "Code": "Product Purpose" } ] } } ] }

CONFIRM anti-Synaptophysin (SP11) Rabbit Monoclonal Primary Antibody

IVD For in vitro diagnostic use.
CONFIRM anti-Synaptophysin (SP11) Rabbit Monoclonal Primary Antibody

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